Heart Health
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Beyond “Estrogen Deficiency”—news from Women’s Health Initiative
The USA’s National Institutes of Health just announced that the Estrogen arm of the Women’s Health Initiative was stopped early (1). Estrogen treatment in women who had undergone hysterectomy was associated with neither benefit nor harm for heart disease and caused a 40% increase in stroke (1). No one can ever again say that estrogen…
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The Death of Hormone Replacement Therapy — Why and how to use Ovarian Hormone Therapy
A response to the cancelled Women’s Health Initiative study and call for a healthier look at menopause Dr. Jerilynn C. Prior, Scientific Director of the Centre for Menstrual Cycle and Ovulation Research, has never advocated the use of hormones as an ongoing “replacement” for menopause. She does not feel that menopause is a medical condition…
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WHI, Five Years Later–WHY no Change
It has been five years since the Women’s Health Initiative (WHI) Estrogen plus Progestin (E plus P) trial was prematurely stopped because it caused harm (1). Until the Estrogen in women with hysterectomy arm (E only) of the WHI was also halted prematurely in 2004 (2), progestin was blamed for the lack of heart disease…
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Estrogen Deficiency: The Wrong Idea About Menopause
The largest and best-controlled trial testing whether hormone “replacement” therapy prevented heart disease was stopped three years early in July 2002. The Women’s Heath Initiative (WHI) study included over 16,600 healthy menopausal women without symptoms. These women were randomized to daily conjugated equine estrogen (Premarin, 0.625 mg) plus medroxyprogesterone (Provera, 2.5 mg) or an identical…